预测土壤中金属和类金属口服生物可利用性的简化方法

[中文适用范围]： 本文档涉及通过摄入土壤评估人体对金属和类金属的暴露。它规定了一种用于预测污染土壤中金属和类金属口服生物可及性的简化方法。该方法是一种使用盐酸（HCl）的化学提取法，至少可用于初步筛选预测土壤样品中砷（As）、镉（Cd）和铅（Pb）的口服生物可及性。它产生的提取物代表了使用经过验证的统一生物可及性方法（UBM）（ISO 17924）测得的生物可及浓度。更具体地说，根据HCl提取的金属和类金属浓度，使用本文档提供的方程和预测区间计算胃相和胃肠相的预测生物可及性，这些方程和区间源自验证研究中获得的简单线性回归数据。注：该简化方法适用于预测土壤中金属和类金属的生物可及性，其中砷、镉和铅的总浓度范围分别为2 mg/kg至2600 mg/kg、0.2 mg/kg至480 mg/kg以及4 mg/kg至50000 mg/kg。 [外文原描述]： This document deals with the assessment of human exposure to metals and metalloids from ingestion of soil. It specifies a simplified method for the prediction of the oral bioaccessibility of metals and metalloids from contaminated soils. The method is a chemical extraction using hydrochloric acid (HCl) and can be used at least for first-tier screening for prediction of the oral bioaccessibility of arsenic (As), cadmium (Cd) and lead (Pb) in soil samples. It produces extracts that are representative of the bioaccessible concentrations measured by using the validated unified bioaccessibility method (UBM) (ISO 17924). More specifically, from the extractable concentrations of metals and metalloids by HCl, the predicted bioaccessibility in both the gastric and gastrointestinal phases is calculated using the equations and the prediction intervals provided in this document, and which have been derived from simple linear regressions of data obtained during validation studies. [ 2 ] NOTE The simplified method is applicable to prediction of the metals and metalloids bioaccessibility in soil with total concentrations range from 2 mg/kg to 2 600 mg/kg for As, from 0,2 mg/kg to 480 mg/kg for Cd, and from 4 mg/kg to 50 000 mg/kg for Pb.